John D. McCorvy: search on Z-Library

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1

Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin

Sherwood, Alexander M., Halberstadt, Adam L., Klein, Adam K., McCorvy, John D., Kaylo, Kristi W., Kargbo, Robert B., Meisenheimer, Poncho

Journal:

Journal of Natural Products

Year:

2020

Language:

english

File:

PDF, 1.65 MB

english, 2020

2

Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775)

Brandt, Simon D., Kavanagh, Pierce V., Twamley, Brendan, Westphal, Folker, Elliott, Simon P., Wallach, Jason, Stratford, Alexander, Klein, Landon M., McCorvy, John D., Nichols, David E., Halberstadt,

Journal:

Drug Testing and Analysis

Year:

2017

Language:

english

File:

PDF, 1.18 MB

english, 2017

3

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

Stein, Reed M., Kang, Hye Jin, McCorvy, John D., Glatfelter, Grant C., Jones, Anthony J., Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S., Stauch, Benjamin, Johansson, Linda C

Journal:

Year:

2020

Language:

english

File:

PDF, 27.26 MB

english, 2020

4

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Wacker, Daniel, Wang, Sheng, McCorvy, John D., Betz, Robin M., Venkatakrishnan, A.J., Levit, Anat, Lansu, Katherine, Schools, Zachary L., Che, Tao, Nichols, David E., Shoichet, Brian K., Dror, Ron O.,

Journal:

Year:

2017

Language:

english

File:

PDF, 5.17 MB

english, 2017

5

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Kroeze, Wesley K, Sassano, Maria F, Huang, Xi-Ping, Lansu, Katherine, McCorvy, John D, Giguère, Patrick M, Sciaky, Noah, Roth, Bryan L

Journal:

Nature Structural and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.71 MB

english, 2015

6

Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

Hansen, Martin, Jacobsen, Stine Engesgaard, Plunkett, Shane, Liebscher, Gudrun Eckhard, McCorvy, John D., Bräuner-Osborne, Hans, Kristensen, Jesper Langgaard

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 517 KB

english, 2015

7

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

Olsen, Reid H. J., DiBerto, Jeffrey F., English, Justin G., Glaudin, Alexis M., Krumm, Brian E., Slocum, Samuel T., Che, Tao, Gavin, Ariana C., McCorvy, John D., Roth, Bryan L., Strachan, Ryan T.

Journal:

Nature Chemical Biology

Year:

2020

File:

PDF, 4.39 MB

2020

8

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models

Cheng, Jianjun, Giguère, Patrick M., Schmerberg, Claire M., Pogorelov, Vladimir M., Rodriguiz, Ramona M., Huang, Xi-Ping, Zhu, Hu, McCorvy, John D., Wetsel, William C., Roth, Bryan L, Kozikowski, Alan

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.61 MB

english, 2015

9

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential

Tan, Liang, Yan, Wenzhong, McCorvy, John D., Cheng, Jianjun

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.19 MB

english, 2018

10

Structural basis of ligand recognition at the human MT1 melatonin receptor

Stauch, Benjamin, Johansson, Linda C., McCorvy, John D., Patel, Nilkanth, Han, Gye Won, Huang, Xi-Ping, Gati, Cornelius, Batyuk, Alexander, Slocum, Samuel T., Ishchenko, Andrii, Brehm, Wolfgang, White

Journal:

Year:

2019

Language:

english

File:

PDF, 8.71 MB

english, 2019

11

Extensive Rigid Analogue Design Maps the Binding Conformation of Potent N -Benzylphenethylamine 5-HT 2A Serotonin Receptor Agonist Ligands

Juncosa, Jose I., Hansen, Martin, Bonner, Lisa A., Cueva, Juan Pablo, Maglathlin, Rebecca, McCorvy, John D., Marona-Lewicka, Danuta, Lill, Markus A., Nichols, David E.

Journal:

ACS Chemical Neuroscience

Year:

2013

Language:

english

File:

PDF, 3.65 MB

english, 2013

12

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

McCorvy, John D, Butler, Kyle V, Kelly, Brendan, Rechsteiner, Katie, Karpiak, Joel, Betz, Robin M, Kormos, Bethany L, Shoichet, Brian K, Dror, Ron O, Jin, Jian, Roth, Bryan L

Journal:

Nature Chemical Biology

Year:

2017

Language:

english

File:

PDF, 4.04 MB

english, 2017

13

Structure-based discovery of opioid analgesics with reduced side effects

Manglik, Aashish, Lin, Henry, Aryal, Dipendra K., McCorvy, John D., Dengler, Daniela, Corder, Gregory, Levit, Anat, Kling, Ralf C., Bernat, Viachaslau, Hübner, Harald, Huang, Xi-Ping, Sassano, Maria F

Journal:

Year:

2016

Language:

english

File:

PDF, 8.35 MB

english, 2016

14

High-Throughput Identification of G Protein-Coupled Receptor Modulators through Affinity Mass Spectrometry Screening

Qin, Shanshan, Meng, Mengmeng, Yang, Dehua, Bai, Wenwen, Lu, Yan, Peng, yao, Song, Gaojie, Wu, Yiran, Zhou, Qingtong, Zhao, Suwen, Huang, Xiping, McCorvy, John D., Cai, Xiaoqing, Dai, Antao, Roth, Bry

Journal:

Chemical Science

Year:

2018

Language:

english

File:

PDF, 1.60 MB

english, 2018

15

Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor

Stauch, Benjamin, Johansson, Linda C., McCorvy, John D., Patel, Nilkanth, Han, Gye Won, Huang, Xi-Ping, Gati, Cornelius, Batyuk, Alexander, Slocum, Samuel T., Ishchenko, Andrii, Brehm, Wolfgang, White

Journal:

Year:

2019

Language:

english

File:

PDF, 309 KB

english, 2019

16

Structural basis of ligand recognition at the human MT1 melatonin receptor

Stauch, Benjamin, Johansson, Linda C., McCorvy, John D., Patel, Nilkanth, Han, Gye Won, Huang, Xi-Ping, Gati, Cornelius, Batyuk, Alexander, Slocum, Samuel T., Ishchenko, Andrii, Brehm, Wolfgang, White

Journal:

Year:

2019

File:

PDF, 8.71 MB

2019

17

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

Chan, John D., McCorvy, John D., Acharya, Sreemoyee, Johns, Malcolm E., Day, Timothy A., Roth, Bryan L., Marchant, Jonathan S., Geary, Timothy G.

Journal:

Year:

2016

Language:

english

File:

PDF, 3.07 MB

english, 2016

18

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

Johansson, Linda C., Stauch, Benjamin, McCorvy, John D., Han, Gye Won, Patel, Nilkanth, Huang, Xi-Ping, Batyuk, Alexander, Gati, Cornelius, Slocum, Samuel T., Li, Chufeng, Grandner, Jessica M., Hao, S

Journal:

Year:

2019

File:

PDF, 7.56 MB

2019

19

Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity

Martini, Michael L., Ray, Caroline, Yu, Xufen, Liu, Jing, Pogorelov, Vladimir M., Wetsel, William C., Huang, Xi-Ping, McCorvy, John D., Caron, Marc G., Jin, Jian

Journal:

ACS Chemical Neuroscience

Year:

2019

Language:

english

File:

PDF, 2.38 MB

english, 2019

20

The chemokine X-factor: structure-function analysis of the CXC motif at CXCR4 and ACKR3

Wedemeyer, Michael J., Mahn, Sarah A., Getschman, Anthony E., Crawford, Kyler S., Peterson, Francis C., Marchese, Adriano, McCorvy, John D., Volkman, Brian F

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 1.97 MB

2020

21

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine

Farrell, Martilias S., McCorvy, John D., Huang, Xi-Ping, Urban, Daniel J., White, Kate L., Giguere, Patrick M., Doak, Allison K., Bernstein, Alison I., Stout, Kristen A., Park, Su Mi, Rodriguiz, Ramon

Journal:

Year:

2016

Language:

english

File:

PDF, 1.45 MB

english, 2016

22

Discovery of G Protein-biased D2 Dopamine Receptor Partial Agonists

Chen, Xin, McCorvy, John D., Fischer, Matthew G, Butler, Kyle V., Shen, Yudao, Roth, Bryan L, Jin, Jian

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

23

Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

Urs, Nikhil M., Gee, Steven M., Pack, Thomas F., McCorvy, John D., Evron, Tama, Snyder, Joshua C., Yang, Xiaobao, Rodriguiz, Ramona M., Borrelli, Emiliana, Wetsel, William C., Jin, Jian, Roth, Bryan L

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.59 MB

english, 2016

24

Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of -lysergic acid diethylamide (LSD)

Halberstadt, Adam L., Chatha, Muhammad, Klein, Adam K., McCorvy, John D., Meyer, Markus R., Wagmann, Lea, Stratford, Alexander, Brandt, Simon D.

Journal:

Neuropharmacology

Year:

2019

Language:

english

File:

PDF, 1.84 MB

english, 2019

25

Comparison of the D1dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease

McCorvy, John D., Watts, Val J., Nichols, David E.

Journal:

Psychopharmacology

Year:

2012

Language:

english

File:

PDF, 235 KB

english, 2012

26

Assessment of dopamine D1 receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393

Alia H. Clark, John D. McCorvy, Val J. Watts, David E. Nichols

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 810 KB

english, 2011

27

Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D1 receptor agonist, and a reversal of enantioselectivity at D1 versus alpha2C adrenergic receptors

Julie A. Przybyla, Juan P. Cueva, Benjamin R. Chemel, K. Joseph Hsu, David J. Riese II, John D. McCorvy, Julia A. Chester, David E. Nichols, Val J. Watts

Journal:

European Neuropsychopharmacology

Year:

2009

Language:

english

File:

PDF, 649 KB

english, 2009

28

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, Katherine, Karpiak, Joel, Liu, Jing, Huang, Xi-Ping, McCorvy, John D, Kroeze, Wesley K, Che, Tao, Nagase, Hiroshi, Carroll, Frank I, Jin, Jian, Shoichet, Brian K, Roth, Bryan L

Journal:

Nature Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

29

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Chan, John D., Cupit, Pauline M., Gunaratne, Gihan S., McCorvy, John D., Yang, Yang, Stoltz, Kristen, Webb, Thomas R., Dosa, Peter I., Roth, Bryan L., Abagyan, Ruben, Cunningham, Charles, Marchant, Jo

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 2.72 MB

english, 2017

30

Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation

Hoehn, Ross D., Nichols, David E., McCorvy, John D., Neven, Hartmut, Kais, Sabre

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

31

Structure and function of serotonin G protein-coupled receptors

McCorvy, John D., Roth, Bryan L.

Journal:

Pharmacology & Therapeutics

Year:

2015

Language:

english

File:

PDF, 1008 KB

english, 2015

32

trans -2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans -2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT 2 receptor family

Pigott, Adam, Frescas, Stewart, McCorvy, John D, Huang, Xi-Ping, Roth, Bryan L, Nichols, David E

Journal:

Beilstein Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 290 KB

english, 2012

33

Discovery of N -Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT 2C ) Receptor Agonists for Potential Use as Antipsychotic Medications

Zhang, Guiping, Cheng, Jianjun, McCorvy, John D., Lorello, Paul J., Caldarone, Barbara J., Roth, Bryan L, Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.99 MB

english, 2017

34

5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

Peng, Yao, McCorvy, John D., Harpsøe, Kasper, Lansu, Katherine, Yuan, Shuguang, Popov, Petr, Qu, Lu, Pu, Mengchen, Che, Tao, Nikolajsen, Louise F., Huang, Xi-Ping, Wu, Yiran, Shen, Ling, Bjørn-Yoshimo

Journal:

Year:

2018

Language:

english

File:

PDF, 6.31 MB

english, 2018

35

D 4 dopamine receptor high-resolution structures enable the discovery of selective agonists

Wang, Sheng, Wacker, Daniel, Levit, Anat, Che, Tao, Betz, Robin M., McCorvy, John D., Venkatakrishnan, A. J., Huang, Xi-Ping, Dror, Ron O., Shoichet, Brian K., Roth, Bryan L.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.40 MB

english, 2017

36

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

Johansson, Linda C., Stauch, Benjamin, McCorvy, John D., Han, Gye Won, Patel, Nilkanth, Huang, Xi-Ping, Batyuk, Alexander, Gati, Cornelius, Slocum, Samuel T., Li, Chufeng, Grandner, Jessica M., Hao, S

Journal:

Year:

2019

Language:

english

File:

PDF, 7.56 MB

english, 2019

37

A 5-HT2C receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference

John D. McCorvy, Aubrie A. Harland, Rebecca Maglathlin, David E. Nichols

Journal:

Neuroscience Letters

Year:

2011

Language:

english

File:

PDF, 189 KB

english, 2011

38

Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism

Zhang, Guiping, McCorvy, John D., Shen, Sida, Cheng, Jianjun, Roth, Bryan L., Kozikowski, Alan P.

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.21 MB

english, 2019

39

Structural determinants of 5-HT2B receptor activation and biased agonism

McCorvy, John D., Wacker, Daniel, Wang, Sheng, Agegnehu, Bemnat, Liu, Jing, Lansu, Katherine, Tribo, Alexandra R., Olsen, Reid H. J., Che, Tao, Jin, Jian, Roth, Bryan L.

Journal:

Nature Structural and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 2.38 MB

english, 2018

40

Design and Discovery of Functionally Selective Serotonin 2C (5-HT 2C ) Receptor Agonists

Cheng, Jianjun, McCorvy, John D., Giguère, Patrick M., Zhu, Hu, Kenakin, Terry, Roth, Bryan L, Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.55 MB

english, 2016

41

Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist

Jensen, Anders A., McCorvy, John D., Petersen, Sebastian Leth, Bundgaard, Christoffer, Liebscher, Gudrun, Kenakin, Terry P., Brauner-Osborne, Hans, Kehler, Jan, Kristensen, Jesper L.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 8.46 MB

english, 2017

42

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon,

Journal:

Year:

2018

Language:

english

File:

PDF, 7.26 MB

english, 2018

43

Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand

Alia H. Clark, John D. McCorvy, Jason M. Conley, Whitney K. Williams, Markondaiah Bekkam, Val J. Watts, David E. Nichols

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 572 KB

english, 2012

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